Spirulina:   Popular treatment for Allergic rhinitis, blood pressure, diabetes, cholesterol, and anemia 

   

 

                              

By Prof. Raphael Nyarkotey Obu

Spirulina is a type of algae that grows in fresh or salt water. It comes as a supplement, in tablet or powder form. 

Spirulina is one of the world’s most popular supplements. It is made from an organism that grows in both fresh and saltwater.

One study by Karkos et al.(2011) explained that spirulina is a type of cyanobacteria , which is a family of single-celled microbes that are often referred to as blue-green algae. Just like plants, cyanobacteria can produce energy from sunlight via a process called photosynthesis.

Spirulina was consumed by the ancient Aztecs but became popular again when NASA proposed that it could be grown in space for use by astronauts( Karkos et al. 2011; Fais et al. 2022).

However, in recent times, many people also used spirulina for different reasons such as to boost the levels of nutrients and antioxidants in their bodies and could protect against various diseases.

Spirulina, science

Nutrients

The US Department of Agriculture revealed that spirulina has nutrients packed. A single tablespoon (tbsp), or 7 grams (g), of dried spirulina powder, has :

• Protein: 4 g

• Thiamin: 14% of the Daily Value (DV)

• Riboflavin: 20% of the DV

• Niacin: 6% of the DV

• Copper: 47% of the DV

• Iron: 11% of the DV

It also has a few amounts of magnesiumpotassium, and manganese.

In addition, the same amount contains only 20 calories and less than 2 g of carbohydrates.

Spirulina also provides a small amount of fat — around 1 g per tbsp (7 g) — including both omega-6 and omega-3 fatty acids in an approximately 1.5 to 1 ratio.

Besides, the quality of the protein in spirulina is regarded as excellent and provides all of the essential amino acids that your body needs.

Though some claimed that spirulina has vitamin B12,  Oeverand Mayer(2022) found this to be false but rather pseudovitaminB12, and not effective in humans.

Antioxidant and anti-inflammatory

The key ingredient in spirulina is called phycocyanin, an antioxidant that also provides a special blue color.

A study by Naeini et al.(2021; Grover et al. 2021)) found that Phycocyanin could wade off oxidative stress by preventing the production of molecules that promote inflammation and providing impressive antioxidant and anti-inflammatory effects.

Cholesterol and triglyceride levels

Serban et al.(2016) study found that Spirulina could reduce total cholesterol, low-density lipoprotein (LDL) or bad cholesterol, and triglycerides, in addition to improving high-density lipoprotein (HDL) or good cholesterol, which are all risk factors for heart disease.

Hamedifard et al.(2019) review found that spirulina improves markers in people with metabolic syndrome and the accompanying disorders.

Protects LDL cholesterol from oxidation

Ito et al.(2019) found that lipid peroxidation is a major contributor to many diseases. They are fatty structures in the body that are susceptible to oxidative damage

A previous study by Wu et al.(2016) found that the antioxidants in spirulina could decrease lipid peroxidation.

A more recent study by Chaouachi et al.(2022) found that spirulina supplements decrease exercise-induced lipid peroxidation, inflammation, and muscle damage in 17 rugby players.

Anti-cancer properties

Fais et al.(2022) animal study found that spirulina reducescancer occurrence and tumor size in various cancers.

Blood pressure

Machowiec et al.(2021) review of five studies found that taking 1-8 g of spirulina per day could significantly reduce both systolic and diastolic blood pressure, especially for people with high blood pressure levels.

The decrease is engineered by an increased production of nitric oxide, a signaling molecule that helps the blood vessels relax and dilate( de Freitas Brito et al. 2019). 

For instance, the Therapeutic Research Centre.com, reports that there’s good evidence that spirulina can help regulate blood pressure and manage hypertension. For instance, a study looked at people diagnosed with hypertension and found that those who took 4.5 grams of spirulina daily for six weeks saw decreases in blood pressure. Another study found that supplementing with 2 grams (g) of spirulina for twelve weeks decreased systolic blood pressure by 7 mmHG and diastolic blood pressure by 6 mmHG.

Allergic rhinitis

Spirulina is a popular alternative treatment for symptoms of allergic rhinitis, and there is evidence that it can be effective.

For instance, Nourollahian et al.(2020) human study found that spirulina was more effective than cetirizine, an antihistamine used to treat allergies, in improving symptoms of allergic rhinitis and decreasing inflammation.

Anemia

Dini Marlina and Fitri Nurhayati(2020) study found spirulinasupplement to improve anemia in pregnant people during the second trimester. A previous study by Othoo et al.(2021) foundspirulina to improve iron deficiency in young children.

Improve muscle strength and endurance

A study by Gurney and Spendiff O(2022) found that spirulinaimproved muscle strength and endurance.

A previous study by Gurney T and Spendiff O(2020) found that spirulina supplementation was able to improve oxygen uptake during an arm cycling exercise, with researchers noting that it could act as an ergogenic aid to enhance athletic performance.

Blood sugar control

Hannan et al.(2020) animal study found that spirulina could lower blood sugar levels.

one review of eight studies by Hatami E et al.(2021) on humans found spirulina supplement from 0.8-8 g daily could drasticallyreduce fasting blood sugar levels in people with type 2 diabetes.

 

The same study found that there was no significant effect on blood sugar levels after eating or levels of hemoglobin A1c, which is used to measure long-term blood sugar control.

Weight loss

Spirulina may be beneficial for people with obesity. Moradi et al (2019) systemic review found that spirulina may reduce body fat percent and waist circumference in people who carry more weight.

However, this meta-analysis only included five studies, so more studies are needed to conclude how spirulina may help with weight loss.

 Oral Health

There are some indications that spirulina can help your oral health.  A study by Mahendra  et al.(2013) found that spirulina gel applied to the gums can help with symptoms of periodontitis (gum disease).

 There is also evidence(Kanjani et al. 2019) that spirulina can fight oral submucous fibrosis (OSMF), a condition that can lead to cancerous lesions in the mouth. However, more studies are needed.

Spirulina, warning

Spirulina is generally considered safe. The Dietary Supplements Information Expert Committee (DSI-EC) has said that it does not pose a major health risk. However, Finamore et al.(2017) study found some side effects such as difficulty sleeping and problems with digestion.

People taking certain blood-pressure-lowering, immunosuppressant, or cholesterol-lowering medications, may need to avoid spirulina due to the potential for interaction with certain chemicals in spirulina. Some products may be contaminated with heavy metals and other toxins or bacteria.

Dosage 

Gogna et al.(2023) study found that people can take spirulina up to 10 grams every day for up to 6 months.

Take Home

Spirulina is a type of cyanobacteria —also known as blue-green algae is highly nutritious and improves cholesterol and triglyceride levels, suppresses oxidation, reduces blood pressure, and lowers fasting blood sugar levels. 

The effects of supplements vary from person to person and depend on many variables, including type, dosage, frequency of use, and interactions with current medications.  This is why it is important to speak to a qualified Naturopathic doctor in this area. Nyarkotey Herbal Pharma has qualified Naturopaths to help you make good decisions on your health on all Natural remedies. Call now 

NB:

Prof. Nyarkotey has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations to justify his write-ups. My articles are for educational purposes and do not serve as Medical advice for Treatment. I aim to educate the public about evidence-based scientific Naturopathic Therapies.

The writer is a Professor of Naturopathic Healthcare, a Medical Journalist, and a science writer. President, NyarkoteyUniversity College of Holistic Medicine & Technology (NUCHMT)/African Naturopathic Foundation, Ashaiman, Ghana. E. mail: professor40naturopathy@gmail.com. Visit-profnyarkotey.com for more. 

Author- “Life in the Gambia-Tales from a Professor and an Aspiring Barrister.”

 

References

1. Karkos PD, Leong SC, Karkos CD, Sivaji N, Assimakopoulos DA. Spirulina in clinical practice: evidence-based human applications. Evid Based Complement Alternat Med. 2011;2011:531053. doi: 10.1093/ecam/nen058. Epub 2010 Oct 19. PMID: 18955364; PMCID: PMC3136577.

2. Fais G, Manca A, Bolognesi F, Borselli M, Concas A, Busutti M, Broggi G, Sanna P, Castillo-Aleman YM, Rivero-Jiménez RA, Bencomo-Hernandez AA, Ventura-Carmenate Y, Altea M, Pantaleo A, Gabrielli G, Biglioli F, Cao G, Giannaccare G. Wide Range Applications of Spirulina: From Earth to Space Missions. Mar Drugs. 2022 Apr 28;20(5):299. doi: 10.3390/md20050299. PMID: 35621951; PMCID: PMC9143897.

3. Naeini F, Zarezadeh M, Mohiti S, Tutunchi H, EbrahimiMamaghani M, Ostadrahimi A. Spirulina supplementation as an adjuvant therapy in enhancement of antioxidant capacity: A systematic review and meta-analysis of controlled clinical trials. Int J Clin Pract. 2021 Oct;75(10):e14618. doi: 10.1111/ijcp.14618. Epub 2021 Aug 4. PMID: 34235823.

4. Grover P, Bhatnagar A, Kumari N, Narayan Bhatt A, Kumar Nishad D, Purkayastha J. C-Phycocyanin-a novel protein from Spirulina platensis- In vivo toxicity, antioxidant and immunomodulatory studies. Saudi J BiolSci. 2021 Mar;28(3):1853-1859. doi: 10.1016/j.sjbs.2020.12.037. Epub 2020 Dec 30. PMID: 33732072; PMCID: PMC7938138.

5. Serban MC, Sahebkar A, Dragan S, Stoichescu-Hogea G, Ursoniu S, Andrica F, Banach M. A systematic review and meta-analysis of the impact of Spirulina supplementation on plasma lipid concentrations. Clin Nutr. 2016 Aug;35(4):842-51. doi: 10.1016/j.clnu.2015.09.007. Epub2015 Sep 25. PMID: 26433766.

6. Hamedifard Z, Milajerdi A, Reiner Ž, Taghizadeh M, Kolahdooz F, Asemi Z. The effects of spirulina on glycemic control and serum lipoproteins in patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2019 Oct;33(10):2609-2621. doi: 10.1002/ptr.6441. Epub 2019 Jul 29. PMID: 31359513.

7. Ito F, Sono Y, Ito T. Measurement and Clinical Significance of Lipid Peroxidation as a Biomarker of Oxidative Stress: Oxidative Stress in Diabetes, Atherosclerosis, and Chronic Inflammation. Antioxidants (Basel). 2019 Mar 25;8(3):72. doi: 10.3390/antiox8030072. PMID: 30934586; PMCID: PMC6466575.

8. Wu Q, Liu L, Miron A, Klímová B, Wan D, Kuča K. The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview. Arch Toxicol. 2016 Aug;90(8):1817-40. doi: 10.1007/s00204-016-1744-5. Epub 2016 Jun 3. PMID: 27259333.

9. Chaouachi M, Gautier S, Carnot Y, Guillemot P, PincemailJ, Moison Y, Collin T, Groussard C, Vincent S. Spirulina supplementation prevents exercise-induced lipid peroxidation, inflammation and skeletal muscle damage in elite rugby players. J Hum Nutr Diet. 2022 Dec;35(6):1151-1163. doi: 10.1111/jhn.13014. Epub 2022 Apr 22. PMID: 35394687.

10. Fais G, Manca A, Bolognesi F, Borselli M, Concas A, Busutti M, Broggi G, Sanna P, Castillo-Aleman YM, Rivero-Jiménez RA, Bencomo-Hernandez AA, Ventura-Carmenate Y, Altea M, Pantaleo A, Gabrielli G, Biglioli F, Cao G, Giannaccare G. Wide Range Applications of Spirulina: From Earth to Space Missions. Mar Drugs. 2022 Apr 28;20(5):299. doi: 10.3390/md20050299. PMID: 35621951; PMCID: PMC9143897.

11. Machowiec P, Ręka G, Maksymowicz M, Piecewicz-Szczęsna H, Smoleń A. Effect of Spirulina Supplementation on Systolic and Diastolic Blood Pressure: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2021 Aug 31;13(9):3054. doi: 10.3390/nu13093054. PMID: 34578932; PMCID: PMC8468496.

12. de Freitas Brito A, Silva AS, de Souza AA, Ferreira PB, de Souza ILL, da Cunha Araujo LC, da Silva Félix G, de Souza Sampaio R, da Conceição Correia Silva M, Tavares RL, de Andrade Pereira R, Neto MM, Silva BA. Supplementation with Spirulina platensis Modulates Aortic Vascular Reactivity through Nitric Oxide and Antioxidant Activity. Oxid Med Cell Longev. 2019 Oct 24;2019:7838149. doi: 10.1155/2019/7838149. PMID: 31772708; PMCID: PMC6854921.

13. Nourollahian M, Rasoulian B, Gafari A, AnoushiravaniM, Jabari F, Bakhshaee M. Clinical comparison of the efficacy of spirulina platensis and cetirizine for treatment of allergic rhinitis. Acta Otorhinolaryngol Ital. 2020 Jun;40(3):224-229. doi: 10.14639/0392-100X-N0139. PMID: 32773785; PMCID: PMC7416373.

14. Dini Marlina and Fitri Nurhayati(2020) The Effectiveness of Spirulina Compared with Iron Supplement on Anemia among Pregnant Women in Indonesia. International Journal of Caring. September -December Volume 13 | Issue 3| Page 1783

15. Othoo, D.A., Ochola, S., Kuria, E. et al. Impact of Spirulina corn soy blend on Iron deficient children aged 6–23 months in Ndhiwa Sub-County Kenya: a randomized controlled trial. BMC Nutr 7, 70 (2021). https://doi.org/10.1186/s40795-021-00472-w

16. Gurney T, Spendiff O. Algae Supplementation for Exercise Performance: Current Perspectives and Future Directions for Spirulina and Chlorella. Front Nutr. 2022 Mar 7;9:865741. doi: 10.3389/fnut.2022.865741. PMID: 35321288; PMCID: PMC8937016.

17. Gurney T, Spendiff O. Spirulina supplementation improves oxygen uptake in arm cycling exercise. Eur J Appl Physiol. 2020 Dec;120(12):2657-2664. doi: 10.1007/s00421-020-04487-2. Epub 2020 Sep 5. PMID: 32892320; PMCID: PMC7674321.

18. Hannan JMA, Ansari P, Azam S, Flatt PR, Abdel WahabYHA. Effects of Spirulina platensis on insulin secretion, dipeptidyl peptidase IV activity and both carbohydrate digestion and absorption indicate potential as an adjunctive therapy for diabetes. Br J Nutr. 2020 Nov 28;124(10):1021-1034. doi: 10.1017/S0007114520002111. Epub 2020 Jun 10. PMID: 32517842; PMCID: PMC7547908.

19. Hatami E, Ghalishourani SS, Najafgholizadeh A, Pourmasoumi M, Hadi A, Clark CCT, Assaroudi M, Salehi-Sahlabadi A, Joukar F, Mansour-Ghanaei F. The effect of spirulina on type 2 diabetes: a systematic review and meta-analysis. J Diabetes Metab Disord. 2021 Mar 2;20(1):883-892. doi: 10.1007/s40200-021-00760-z. PMID: 34178867; PMCID: PMC8212345.

20. Finamore A, Palmery M, Bensehaila S, Peluso I. Antioxidant, Immunomodulating, and Microbial-Modulating Activities of the Sustainable and Ecofriendly Spirulina. Oxid Med Cell Longev. 2017;2017:3247528. doi: 10.1155/2017/3247528. Epub2017 Jan 15. PMID: 28182098; PMCID: PMC5274660.

21. Gogna S, Kaur J, Sharma K, Prasad R, Singh J, BhadariyaV, Kumar P, Jarial S. Spirulina- An Edible Cyanobacterium with Potential Therapeutic Health Benefits and Toxicological Consequences. J Am Nutr Assoc. 2023 Aug;42(6):559-572. doi: 10.1080/27697061.2022.2103852. Epub 2022 Aug 2. PMID: 35916491.

22. Moradi S, Ziaei R, Foshati S, et al. Effects of Spirulina supplementation on obesity: A systematic review and meta-analysis of randomized clinical trials. Complementary Therapies in Medicine. 2019;47:102211. doi:10.1016/j.ctim.2019.102211

23. Mahendra J, Mahendra L, Muthu J, et al. Clinical effects of subgingivally delivered spirulina gel in chronic periodontitis cases: A placebo controlled clinical trial. Journal of Clinical and Diagnostic Research. 2013;7(10):2330-3. doi:10.7860/JCDR/2013/5793.3517

24. Kanjani V, Annigeri R, Revanappa M, Rani A. Efficacy of spirulina along with different physiotherapeutic modalities in the management of oral submucous fibrosis. Ann Maxillofac Surg. 2019;9(1):23. doi:10.4103/ams.ams_3_19